H-Cube^®

A revolutionary bench-top standalone hydrogenation reactor, uniquely combining continuous-flow microchemistry with endogenous on-demand hydrogen generation and a disposable catalyst cartridge system. It allows fast and cost-efficient hydrogenation with superior yield when compared to conventional methods.

Continuous hydrogenation reactions are performed in a flow system. The hydrogen gas necessary for the reaction is generated in-situ. Reactions take place on disposable proprietary CatCarts®, packed catalyst columns modeled after conventional HPLC systems, ensuring excellent lab integration and ease of use.

Every aspect of the operation on the H-Cube® is controlled and monitored using a touch-screen panel. With no external storage of hydrogen necessary, the H-Cube® may be used safely in almost any laboratory environment, while its minimal "footprint" maximizes available bench space.

Key features

• A continuous-flow of substrate is combined with hydrogen, generated in-situ from the electrolysis of water.
• The Hydrogen/Substrate mixture can be heated and pressurized up to 100 °C (212 °F) and 100 bar (1450 psi) respectively.
• The mixture is then passed through a packed catalyst cartridge (CatCart®), where the reaction takes place, and the product continuously elutes out of the CatCart® and into a collection vial.
• Excellent potential for automated high-throughput hydrogenation when integrated with a liquid handler.
• Within 5 minutes, product emerges for fast reduction and optimization. Reductions varying in scale from 10 mg-100 g can be performed on the same compact reactor.